PHD project in Microbiology and Dermatology Identified associations with commensal community dysregulation related to dermatological pathologies, which encompass widespread conditions, such as acne vulgaris and seborrheic or atopic dermatitis. Introduction The anaerobic bacterium Propionibacterium acnes is believed to play an important role in the pathophysiology of the common skin disease acne vulgaris. Understanding of the taxonomic and intraspecies diversity of the bacterium has increased tremendously, and with it the realisation that particular strains are associated with skin health while others appear related to disease. Objective The Aim of the study explore some of the clinical and metagenomic changes in acne-prone skin, providing insights into why certain lineages appear to have a heightened capacity to contribute to acne vulgaris development. while others are positively associated with skin health. Methods We aim to cover our current knowledge regarding the association of P. acnes phylogroups, clonal complexes biomedical tests, and sequence types with acne vulgaris based on multilocus sequence typing of isolates, as well as investigation of host-microbe interactions. Guidance on writing my research proposal Title: Author (ie my name) Abstract: 250 words MAXIMUM (to be used for ATAS if required) Keywords: Maximum 8 Background Information/Literature Review: Ie what is known on this topic, what are the data gaps, what information leads you to the hypothesis you are proposing to test? Aims and Objectives: Aims: What is the research question? what is the hypothesis you wish to test? Objectives: What do you plan to find out? ie what piece(s) of information do you plan to generate and what will they tell us? Approach/Methodology: How do you plan to do this? Primary/secondary information sources If primary: what methods will you use (e g laboratory and /or field), and why. What are the pros and cons. What will be the limits on the knowledge you will generate from this approach? What statistical methods may be available to assist your analysis and interpretation? If secondary: What information sources are available to you (peer-reviewed, ‘grey literature’, web-based, published, unpublished database) Are there any issues with access (cost, authorisation)? What are the limitations on the knowledge you will generate from this approach (is there likely to be any systematic error/bias arising from the type of information you will rely on)? Research Plan: Briefly summarise project progression, provide some intermediate milestones This may include a Gantt Chart for the three years leading to submission date. Risk Assessment and budget (brief) Primary Sources (eg Lab/field work) Secondary Sources Budget: any significant resources that IfE does not have and how you plan to acquire them.